Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death
worldwide and has few effective therapies. It is characterized by anomalous and persistent …

In this review we summarize recent major advances in our understanding on the molecular
mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary …

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. It is
characterized by alterations of the alveolar epithelium, myofibroblast activation, and …

The inflammatory bowel diseases (IBDs; Crohn's disease, and ulcerative colitis) are
chronically relapsing inflammatory disorders of the intestine and/or colon. The precise …

Rationale: Alveolar epithelial cells (AECs) play central roles in the response to lung injury
and the pathogenesis of pulmonary fibrosis. Objectives: We aimed to determine the role of β …

Rationale: Injury to alveolar epithelial cells (AECs) and to their repair process is integral to
the pathogenesis of acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF). The …

Inflammatory conditions can profoundly alter human neutrophils, a leukocyte subset
generally viewed as terminally differentiated and catabolic. In cystic fibrosis (CF) patients …

Repair of the lung epithelium after injury is integral to the pathogenesis and outcomes of
diverse inflammatory lung diseases. We previously reported that β-catenin signaling …

The respiratory epithelium plays a critical role in innate defenses against airborne
pathogens and pollutants, and alterations in epithelial homeostasis and repair mechanisms …

Alveolar epithelial damage is a critical event that leads to protein-rich edema in acute lung
injury (ALI), but the mechanisms leading to epithelial damage are not completely …