Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …

Autophagy is an evolutionarily conserved process that promotes the lysosomal degradation
of intracellular components including organelles and portions of the cytoplasm. Besides …

Background: Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular
endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to …

One of the most important mechanisms that promotes metastasis is the stabilization of Hif-1
(hypoxia-inducible transcription factor 1). We decided to test whether Hif-1α also was …

Background Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of
STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively …

Hypoxia is a prevalent attribute of the solid tumor microenvironment that promotes the
expression of genes through posttranslational modifications and stabilization of alpha …

The essential base excision repair protein, apurinic/apyrimidinic endonuclease 1 (APE1),
plays an important role in redox regulation in cells and is currently targeted for the …

There is a need for efficacious therapies for metastatic castration-resistant prostate cancer
(mCRPC) after disease progression on docetaxel. The SRC tyrosine kinase and its related …

Background: The PIAS4 protein belongs to the family of protein inhibitors of activated STAT,
but has since been implicated in various biological activities including the post-translational …

Abstract Purpose: Dasatinib is an Src family kinase inhibitor with modest activity in advanced
breast cancer. We aimed to assess toxicity and maximum tolerated dose (MTD) for dasatinib …