Treatment of infant leukemias: challenge and promise

P Brown - Hematology 2013, the American Society of …, 2013 - ashpublications.org
Leukemia in infants is rare but generates tremendous interest due to its aggressive clinical
presentation in a uniquely vulnerable host, its poor response to current therapies, and its …

Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

F Mussai, C De Santo, I Abu-Dayyeh… - Blood, The Journal …, 2013 - ashpublications.org
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the second
most common frequent leukemia of childhood. Patients may present with lymphopenia or …

Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia

A Pession, R Masetti, C Rizzari, MC Putti… - Blood, The Journal …, 2013 - ashpublications.org
We evaluated the outcome of 482 children with acute myeloid leukemia (AML) enrolled in
the Associazione Italiana di Ematologia e Oncologia Pediatrica AML 2002/01 trial …

NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern

JDE de Rooij, IHIM Hollink, S Arentsen-Peters… - Leukemia, 2013 - nature.com
Cytogenetic abnormalities and early response to treatment are the main prognostic factors in
acute myeloid leukemia (AML). Recently, NUP98/NSD1 (t (5; 11)(q35; p15)), a …

Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children

D Tomizawa, A Tawa, T Watanabe, AM Saito, K Kudo… - Leukemia, 2013 - nature.com
Patients with core binding factor acute myeloid leukemia (CBF-AML) with translocation (8;
21)(q22; q22)[t (8; 21)] and inversion of chromosome 16 (p13. 1q22), or its variant t (16; …

Nutritional status and dietary intake of children with acute leukaemia during induction or consolidation chemotherapy

SY Tan, BK Poh, MH Nadrah… - Journal of Human …, 2013 - Wiley Online Library
Background The assessment of nutritional status among paediatric patients is important for
the planning and execution of nutritional strategies that strive to optimise the quality of life …

Appropriate dose reduction in induction therapy is essential for the treatment of infants with acute myeloid leukemia: a report from the Japanese Pediatric Leukemia …

D Tomizawa, A Tawa, T Watanabe, AM Saito… - International journal of …, 2013 - Springer
Abstract Infants (< 1 year old) with acute myeloid leukemia (AML) are particularly vulnerable
to intensive cytotoxic therapy. Indeed, the mortality rate was high among infants enrolled in …

Outcome of adolescents and young adults with acute myeloid leukemia treated on COG trials compared to CALGB and SWOG trials

WG Woods, ARK Franklin, TA Alonzo, RB Gerbing… - Cancer, 2013 - Wiley Online Library
BACKGROUND A retrospective meta‐analysis of adolescents and young adults (AYAs) with
acute myeloid leukemia (AML) was performed to determine if differences in outcome exist …

Use of zoledronic acid for treatment of chemotherapy related osteonecrosis in children and adolescents: a retrospective analysis

B Padhye, L Dalla‐Pozza, DG Little… - Pediatric blood & …, 2013 - Wiley Online Library
Background Osteonecrosis (ON) is a disabling complication of chemotherapy, especially
steroids in children and adolescents. There are few reports in the literature of non‐surgical …

Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions

KJ August, A Narendran, KA Neville - Drugs, 2013 - Springer
Over the past 50 years, numerous advances in treatment have produced dramatic increases
in the cure rates of pediatric leukemias. Despite this progress, the majority of children with …