Muscle wasting is associated with a wide range of catabolic diseases. This debilitating loss
of muscle mass and functional capacity reduces the quality of life and increases the risks of …

Skeletal muscle is a highly specialized, postmitotic tissue that must withstand chronic
mechanical and physiological stress throughout life to maintain proper contractile function …

Introduction ACE‐031 is a soluble form of activin receptor type IIB (ActRIIB). ACE‐031
promotes muscle growth by binding to myostatin and other negative regulators of muscle …

Loss of muscle and bone mass with age are significant contributors to falls and fractures
among the elderly. Myostatin deficiency is associated with increased muscle mass in mice …

Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin
precursor by multiple steps of proteolytic processing. After cleavage by a furin‐type …

Skeletal muscle stem cells, satellite cells, are normally quiescent but become activated upon
muscle injury. Recruitment of resident satellite cells may be a useful strategy for treatment of …

Certain disclosed oligomers induce exon skipping during processing of myostatin pre-
mRNA. The oligomers may be in a vector or encoded by the vector. The vector is used for …

Skeletal muscle mass is regulated by a balance of protein synthesis and degradation. The
regulation of this protein synthesis/degradation system is linked with muscle activity, and …

J'adresse donc mes plus sincères remerciements à Didier MONTARRAS et à Pascal MAIRE
de m'avoir fait l'honneur d'être rapporteurs de cette thèse. Merci à Anne BONNIEU, Marie …

La cachexie est un syndrome clinique et métabolique caractérisé par une perte de tissu
adipeux et de tissu musculaire, fréquemment observé chez les patients atteints de cancer …