BackgroundSummarizing the epidemiology of major depressive disorder (MDD) at a global
level is complicated by significant heterogeneity in the data. The aim of this study is to …

Background Previous reviews on risk and protective factors for violence in psychosis have
produced contrasting findings. There is therefore a need to clarify the direction and strength …

Rationale The role of biomarkers such as troponin in risk stratification of sepsis is still
debated. The aim of this meta-analysis is to assess the relation between troponin elevation …

Background Systematic reviews provide clinical practice recommendations that are based
on evaluation of primary evidence. When systematic reviews with the same aims have …

Background Critics of systematic reviews have argued that these studies often fail to inform
clinical decision making because their results are far too general, that the data are sparse …

Background The placebo effect often undermines efforts to determine treatment
effectiveness in clinical trials. A significant placebo response occurs in alcohol trials, but it is …

Abstract The Childhood Autism Rating Scale (CARS) is a popular behavior-observation
instrument that was developed more than 34 years ago and has since been adopted in a …

The aim of this study is to determine the diagnostic accuracy of contrast-enhanced
ultrasonography (CEUS) for diagnosis of small (≤ 2 cm in diameter) hepatocellular …

Policymakers from developed countries who are looking to commission breastfeeding peer
support (BPS) services have every cause to be puzzled as to whether or not they can …

Our study revisits and challenges two core conventional meta-regression models: the
prevalent use of 'mixed-effects' or random-effects meta-regression analysis (RE-MRA) and …