Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone
and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin …

Sažetak Bone and immune system are functionally interconnected. Immune and bone cells
derive from same progenitors in the bone marrow, they share a common microenvironment …

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that
regulates the expression of a variety of antioxidant and detoxification genes through an …

The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and
collagenolytic enzymes. The molecular mechanisms underlying metabolic adaptation to the …

Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including
chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent …

Biotherapies have revolutionized the treatment of RA. However, much work is needed to
understand all the mechanisms of these biotherapies, and alternatives are needed to …

Bone resorption by osteoclasts requires a large number of lysosomes that release proteases
in the resorption lacuna. Whether lysosomal biogenesis is a consequence of the action of …

Osteoclasts are multinucleated myeloid lineage cells formed in response to macrophage
colony‐stimulating factor (M‐CSF) and receptor activator of NF‐κB ligand (RANKL) by fusion …

Introduction Increased activity of osteoclasts is responsible for bone loss and joint
destruction in rheumatoid arthritis. For osteoclast development and bone resorption activity …

RA is a chronic autoimmune disease characterized by joint synovial inflammation and
progressive cartilage/bone destruction. Although various kinds of RA drug have been …