The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts
HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …
The nurd architecture
HF Allen, PA Wade, TG Kutateladze - Cellular and Molecular Life Sciences, 2013 - Springer
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin
organization, gene transcription, genomic stability and developmental signaling. NuRD has …
organization, gene transcription, genomic stability and developmental signaling. NuRD has …
[PDF][PDF] Class I HDACs share a common mechanism of regulation by inositol phosphates
CJ Millard, PJ Watson, I Celardo, Y Gordiyenko… - Molecular cell, 2013 - cell.com
Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate
corepressor proteins into specific transcriptional repression complexes that target HDAC …
corepressor proteins into specific transcriptional repression complexes that target HDAC …
[HTML][HTML] Methylation-dependent and-independent genomic targeting principles of the MBD protein family
To gain insight into the cellular readout of DNA methylation, we established a strategy for
systematically profiling the genome-wide distribution of chromatin-interacting factors. This …
systematically profiling the genome-wide distribution of chromatin-interacting factors. This …
Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells
Abstract Background Ten-Eleven Translocation (TETs) proteins mediate the oxidation of 5-
methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels …
methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels …
NuRD blocks reprogramming of mouse somatic cells into pluripotent stem cells
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by
overexpression of a defined set of transcription factors requires epigenetic changes in …
overexpression of a defined set of transcription factors requires epigenetic changes in …
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
K Günther, M Rust, J Leers, T Boettger… - Nucleic acids …, 2013 - academic.oup.com
The heterogeneous collection of nucleosome remodelling and deacetylation (NuRD)
complexes can be grouped into the MBD2-or MBD3-containing complexes MBD2–NuRD …
complexes can be grouped into the MBD2-or MBD3-containing complexes MBD2–NuRD …
MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer
Aberrant regulation of histone deacetylase 2 (HDAC2) plays a pivotal role in the
development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to …
development of hepatocellular carcinoma (HCC), but, the underlying mechanism leading to …
An evolving understanding of nuclear receptor coregulator proteins
CJ Millard, PJ Watson, L Fairall… - Journal of molecular …, 2013 - jme.bioscientifica.com
Nuclear receptors are transcription factors that regulate gene expression through the ligand-
controlled recruitment of a diverse group of proteins known as coregulators. Most nuclear …
controlled recruitment of a diverse group of proteins known as coregulators. Most nuclear …
The chromodomain helicase Chd4 is required for Polycomb‐mediated inhibition of astroglial differentiation
A Sparmann, Y Xie, E Verhoeven, M Vermeulen… - The EMBO …, 2013 - embopress.org
Polycomb group (PcG) proteins form transcriptional repressor complexes with well‐
established functions during cell‐fate determination. Yet, the mechanisms underlying their …
established functions during cell‐fate determination. Yet, the mechanisms underlying their …