Diagnosis of multiple sclerosis (MS) requires the exclusion of other possible diagnoses. For
this reason, the cerebrospinal fluid (CSF) should be routinely analysed in patients with a first …

Multiple sclerosis (MS) is a chronic disorder of the central nervous system (CNS) in which
the complex interplay between inflammation and neurodegeneration determines varying …

Background: There is a lack of reliable biomarkers of axonal degeneration. Neurofilaments
are promising candidates to fulfil this task. We compared two highly sensitive assays to …

The choice of appropriate control group (s) is critical in cerebrospinal fluid (CSF) biomarker
research in multiple sclerosis (MS). There is a lack of definitions and nomenclature of …

Multiple sclerosis (MS) is a progressive immune‑mediated disease caused by demyelination
of the central nervous system. Cytokines and their receptors have an important role in the …

BACKGROUND: Soluble oligomers of amyloid ß-protein (Aß) have been increasingly linked
to synaptic dysfunction, tau alteration, and neuritic dystrophy in Alzheimer's disease (AD) …

Parkinson's disease (PD) is characterized neuropathologically by the cytoplasmic
accumulation of misfolded α‐synuclein in specific brain regions. The endolysosomal …

Background: Axonal damage is considered a major cause of disability in multiple sclerosis
(MS) and may start early in the disease. Specific biomarkers for this process are of great …

In the present study, we aimed to discover cerebrospinal fluid (CSF) proteins with significant
abundance difference between early multiple sclerosis patients and controls, and do an …

A release of light neurofilament subunits (NFL) into cerebrospinal fluid (CSF) and serum in
multiple sclerosis (MS) may induce an immune response. We examined CSF and serum …