Endomorphin derivatives with improved pharmacological properties
P Varamini, JT Blanchfield, I Toth - Current medicinal chemistry, 2013 - ingentaconnect.com
Centrally acting opioids, such as morphine, are the most frequently used analgesic agents
for the treatment of severe pain. However, their usefulness is limited by the production of a …
for the treatment of severe pain. However, their usefulness is limited by the production of a …
Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain
While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-
aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism (s) …
aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism (s) …
Peripherally acting novel lipo-endomorphin-1 peptides in neuropathic pain without producing constipation
P Varamini, WH Goh, FM Mansfeld… - Bioorganic & medicinal …, 2013 - Elsevier
We previously described two novel analogues of endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, 1),
modified with an 8-carbon lipoamino acid (C8LAA) with or without replacement of Tyr1 with …
modified with an 8-carbon lipoamino acid (C8LAA) with or without replacement of Tyr1 with …
Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion
Previously, we have synthesized an endomorphin-2 (EM-2) analog with C-terminal amide to
hydrazide conversion, exhibiting slightly lower μ-affinity than EM-2. In the present study, the …
hydrazide conversion, exhibiting slightly lower μ-affinity than EM-2. In the present study, the …
In vivo characterization of intestinal effects of endomorphin-1 and endomorphin-2 in type 1 diabetic mice
C Wang, Y Zhou, C Guo, Y Zhang, R Wang - European journal of …, 2013 - Elsevier
Previously, we have demonstrated that type 1 diabetes significantly attenuated the effects of
endomorphins on mouse colonic contractions in vitro. In the present study, to further assess …
endomorphins on mouse colonic contractions in vitro. In the present study, to further assess …
[PDF][PDF] The important role of GLUT2 in intestinal sugar absorption
E Stelmanska - POSTĘPY| BIOCHEMII - rcin.org.pl
The classical model of sugar absorption indicates that Na+-glucose cotransporter, SGLT1
transports glucose from intestinal lumen to cytosol and GLUT2 transports glucose from …
transports glucose from intestinal lumen to cytosol and GLUT2 transports glucose from …