We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Objective: Pharmacological treatment is considered indispensable to major depressive
disorder. In spite of this, a significant number of patients do not respond adequately to …

Background Antidepressants are often the first-line treatment for depression in primary care.
However, not all patients respond to medication after an adequate dose and duration of …

Depression is one of the most frequent and severe mental disorder. Since the discovery of
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …

Whereas animal models of depression are associated with decreased adult hippocampal
neurogenesis, antidepressant treatments, including pharmacotherapy but also …

BackgroundFindings of brain structural changes in major depressive disorder are still
inconsistent, partly because some crucial clinical variables have not been taken into …

Background Recently, we reported that low reward dependence, and to a lesser extent, low
cooperativeness in the Temperature and Character Inventory (TCI) may be risk factors for …

Treatment resistant depression (TRD) is a significant clinical and public health problem.
Among others, neuroplasticity and inflammatory pathways seem to play a crucial role in the …

BACKGROUND: Axis I comorbidity in mood disorders was common in epidemiological
studies. This study was designed to investigate the prevalence, pattern, and number of Axis I …

Objective: Some studies report that initial anxiety is associated with equivocal or negative
effects in depression treatment. In contrast, at least 4 studies of cognitive behavioral therapy …