Objectives The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown
of acetylcholine, is currently the main pharmacological strategy available for Alzheimer's …

Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

With the aging population and its rapidly increasing prevalence, dementia has become an
important public health concern in developed and developing countries. To date, the …

Alzheimer´ s disease (AD) is a progressive neurodegenerative dementia which currently
represents one of the biggest threats for the human kind. The cure is still unknown and …

Neurodegenerative, neurological and psychiatric diseases are a group of pathologies with
huge social and economic impacts. Since brain disorders continue to be pathological …

Hot extraction with acetone was the most efficient method for the extraction of fucoxanthin
from Phaeodactylum tricornutum. The purified compound resulted in three main peaks …

A series of fused coumarins namely 5-oxo-4, 5-dihydropyrano [3, 2-c] chromenes linked to N-
benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) …

Abstract A series of N-{2-[4-(1H-benzimidazole-2-yl) phenoxy] ethyl} substituted amine
derivatives were designed to assess cholinesterase inhibitor activities. Acetylcholinesterase …

Acetylcholinesterase (AChE) is a main drug target, and its inhibitors have demonstrated
functionality in the symptomatic treatment of Alzheimer's disease (AD). In this study, a series …