Anti-infective carbonic anhydrase inhibitors: a patent and literature review

C Capasso, CT Supuran - Expert opinion on therapeutic patents, 2013 - Taylor & Francis
Introduction: All microorganisms that cause diseases or illnesses to their host are defined as
pathogens. In this paper we will review the current state of the art for inhibiting parasite …

Elucidating the Immunological Function of the Cryptococcus Neoformans Capsule

A Vecchiarelli, E Pericolini, E Gabrielli… - Future …, 2013 - Taylor & Francis
The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent
of life-threatening infections in immunocompromised subjects. A unique characteristic of …

Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses

TR O'Meara, SM Holmer, K Selvig, F Dietrich… - MBio, 2013 - Am Soc Microbiol
Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …

Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans

A Singh, RJ Panting, A Varma, T Saijo, KJ Waldron… - MBio, 2013 - Am Soc Microbiol
Urease in Cryptococcus neoformans plays an important role in fungal dissemination to the
brain and causing meningoencephalitis. Although urea is not required for synthesis of …

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

TB Liu, JC Kim, Y Wang, DL Toffaletti, E Eugenin… - PLoS …, 2013 - journals.plos.org
Cryptococcus neoformans is the most common cause of fungal meningitis, with high
mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in …

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence

KL Ormerod, CA Morrow, EWL Chow… - G3: Genes …, 2013 - academic.oup.com
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality
among the human immunodeficiency virus/acquired immunodeficiency syndrome …

Characterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans

IR Lee, L Yang, G Sebetso, R Allen, THN Doan… - PloS one, 2013 - journals.plos.org
Degradation of purines to uric acid is generally conserved among organisms, however, the
end product of uric acid degradation varies from species to species depending on the …

[PDF][PDF] Potential clinical significance of urease enzyme

B Sujoy, A Aparna - European Scientific Journal, 2013 - core.ac.uk
Urease belongs to the super family of amidohydrolases and phosphotriestreases. Urease
involves the nitrogen metabolism; urea degradation; generating CO2 and NH3 from urea …

Nitrogen regulation of virulence in clinically prevalent fungal pathogens

IR Lee, CA Morrow, JA Fraser - FEMS microbiology letters, 2013 - academic.oup.com
The habitats of fungal pathogens range from environmental to commensal, and the nutrient
content of these different niches varies considerably. Upon infection of humans, nutrient …

Reactive Oxygen Species Homeostasis and Virulence of the Fungal Pathogen Cryptococcus neoformans Requires an Intact Proline Catabolism Pathway

IR Lee, EYL Lui, EWL Chow, SDM Arras, CA Morrow… - Genetics, 2013 - academic.oup.com
Degradation of the multifunctional amino acid proline is associated with mitochondrial
oxidative respiration. The two-step oxidation of proline is catalyzed by proline oxidase and …