Anti-infective carbonic anhydrase inhibitors: a patent and literature review
C Capasso, CT Supuran - Expert opinion on therapeutic patents, 2013 - Taylor & Francis
Introduction: All microorganisms that cause diseases or illnesses to their host are defined as
pathogens. In this paper we will review the current state of the art for inhibiting parasite …
pathogens. In this paper we will review the current state of the art for inhibiting parasite …
Elucidating the Immunological Function of the Cryptococcus Neoformans Capsule
A Vecchiarelli, E Pericolini, E Gabrielli… - Future …, 2013 - Taylor & Francis
The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent
of life-threatening infections in immunocompromised subjects. A unique characteristic of …
of life-threatening infections in immunocompromised subjects. A unique characteristic of …
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses
TR O'Meara, SM Holmer, K Selvig, F Dietrich… - MBio, 2013 - Am Soc Microbiol
Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …
Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans
A Singh, RJ Panting, A Varma, T Saijo, KJ Waldron… - MBio, 2013 - Am Soc Microbiol
Urease in Cryptococcus neoformans plays an important role in fungal dissemination to the
brain and causing meningoencephalitis. Although urea is not required for synthesis of …
brain and causing meningoencephalitis. Although urea is not required for synthesis of …
Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier
Cryptococcus neoformans is the most common cause of fungal meningitis, with high
mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in …
mortality and morbidity. The reason for the frequent occurrence of Cryptococcus infection in …
Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence
KL Ormerod, CA Morrow, EWL Chow… - G3: Genes …, 2013 - academic.oup.com
The opportunistic fungal pathogen Cryptococcus neoformans is a leading cause of mortality
among the human immunodeficiency virus/acquired immunodeficiency syndrome …
among the human immunodeficiency virus/acquired immunodeficiency syndrome …
Characterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans
IR Lee, L Yang, G Sebetso, R Allen, THN Doan… - PloS one, 2013 - journals.plos.org
Degradation of purines to uric acid is generally conserved among organisms, however, the
end product of uric acid degradation varies from species to species depending on the …
end product of uric acid degradation varies from species to species depending on the …
[PDF][PDF] Potential clinical significance of urease enzyme
B Sujoy, A Aparna - European Scientific Journal, 2013 - core.ac.uk
Urease belongs to the super family of amidohydrolases and phosphotriestreases. Urease
involves the nitrogen metabolism; urea degradation; generating CO2 and NH3 from urea …
involves the nitrogen metabolism; urea degradation; generating CO2 and NH3 from urea …
Nitrogen regulation of virulence in clinically prevalent fungal pathogens
The habitats of fungal pathogens range from environmental to commensal, and the nutrient
content of these different niches varies considerably. Upon infection of humans, nutrient …
content of these different niches varies considerably. Upon infection of humans, nutrient …
Reactive Oxygen Species Homeostasis and Virulence of the Fungal Pathogen Cryptococcus neoformans Requires an Intact Proline Catabolism Pathway
IR Lee, EYL Lui, EWL Chow, SDM Arras, CA Morrow… - Genetics, 2013 - academic.oup.com
Degradation of the multifunctional amino acid proline is associated with mitochondrial
oxidative respiration. The two-step oxidation of proline is catalyzed by proline oxidase and …
oxidative respiration. The two-step oxidation of proline is catalyzed by proline oxidase and …