Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

Ageing is a potent, independent risk factor for cardiovascular disease. Calcification of the
vascular smooth muscle cell (VSMC) layer of the vessel media is a hallmark of vascular …

Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease that is
frequently caused by a de novo point mutation at position 1824 in LMNA. This mutation …

Rationale: Vascular calcification is prevalent in the aging population, yet little is known of the
mechanisms driving age-associated vascular smooth muscle cell (VSMC) phenotypic …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare segmental premature aging
disorder that recapitulates some biological and physical aspects of physiological aging. The …

A balance must be struck between cell growth and stress responses to ensure that cells
proliferate without accumulating damaged DNA. This balance means that optimal cell …

The role of protein farnesylation in lamin A biogenesis and the pathogenesis of progeria has
been studied in considerable detail, but the importance of farnesylation for the B-type …

Objective—Some mutations in LMNA, encoding A-type lamins, are responsible for Dunnigan-
type-familial partial lipodystrophy (FPLD2), with altered fat distribution and metabolism. The …

The posttranslational modification of protein prenylation is a covalent lipid modification on
the C-terminus of substrate proteins that serves to enhance membrane affinity. Oncogenic …

Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that
are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and …