Are tau aggregates toxic or protective in tauopathies?
CM Cowan, A Mudher - Frontiers in neurology, 2013 - frontiersin.org
Aggregation of highly phosphorylated tau into aggregated forms such as filaments and
neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease …
neurofibrillary tangles is one of the defining pathological hallmarks of Alzheimer's disease …
Animal models of neurodegenerative diseases
The prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and
Parkinson's disease (PD), increases with age, and the number of affected patients is …
Parkinson's disease (PD), increases with age, and the number of affected patients is …
Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease
SW Ho, YTC Tsui, TT Wong, SKK Cheung… - Translational …, 2013 - Springer
Abstract Alzheimer's disease (AD), the most common dementia, is characterized by
potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as …
potentially neurotoxic aggregation of Aβ peptide and tau protein, and their deposition as …
Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity
J Knäblein, R Huber - Modern Biopharmaceuticals, 2013 - Wiley Online Library
Since we appeared on our planet, mankind dreamed of being forever young, healthy, vital,
and to live indefinitely–and this desire to last forever is part of our human nature. But in …
and to live indefinitely–and this desire to last forever is part of our human nature. But in …
Aβ-Mediated Changes in CREB and ERK Activity in Cultured Cortical Neurons: Involvement of NMDA Receptors
V de Rosa - 2013 - search.proquest.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly.
Typical hallmarks of this pathology are the extracellular deposits of amyloid-beta peptide …
Typical hallmarks of this pathology are the extracellular deposits of amyloid-beta peptide …
Characterization of antibodies recognizing pathological forms of Tau in Alzheimer's disease
AFD Marreiro - 2013 - estudogeral.uc.pt
Alzheimer's Disease is a critical neurodegenerative disease characterized by two hallmarks,
deposition of Aβ protein in plaques and incorporation of Tau proteinaceous aggregates in …
deposition of Aβ protein in plaques and incorporation of Tau proteinaceous aggregates in …