The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

Mitochondria are independent organelles with their own DNA. As a primary function,
mitochondria produce the energy for the cell through Oxidative Phosphorylation (OXPHOS) …

Mitochondrial DNA (mtDNA) variation can affect phenotypic variation; therefore, knowing its
distribution within and among individuals is of importance to understanding many human …

Background The mitochondrial genome (mtDNA) is particularly susceptible to damage
mediated by reactive oxygen species (ROS). Although elevated ROS production and …

Age-at-death estimation is one of the main challenges in forensic sciences since it
contributes to the identification of individuals. There are many anthropological techniques to …

A significant body of work, accumulated over the years, strongly suggests that damage in
mitochondrial DNA (mtDNA) contributes to aging in humans. Contradictory results, however …

Cardiovascular disease is a major cause of morbidity and mortality in the United States.
While many studies have focused upon the effects of adult second-hand smoke exposure on …

In the 14 years, since the first disease-causing mitochondrial DNA (mtDNA) mutations were
reported, hundreds of pathogenic mutations have been identified in both the mtDNA and the …

Recent breakthroughs have provided notable insights into both the pathogenesis and
therapeutic strategies for age-related hearing loss (ARHL). Simultaneously, these …

The causes of ageing remain poorly understood, although a role for mitochondria is widely
accepted. These unique organelles that are responsible for a cell's energy, rely on their own …