Organizing principles of mammalian nonsense-mediated mRNA decay
MWL Popp, LE Maquat - Annual review of genetics, 2013 - annualreviews.org
Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …
Nonsense-mediated mRNA decay—mechanisms of substrate mRNA recognition and degradation in mammalian cells
C Schweingruber, SC Rufener, D Zünd… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …
coupled quality control system that recognizes and degrades aberrant mRNAs with …
Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3′ UTRs
Recruitment of the UPF1 nonsense-mediated mRNA decay (NMD) factor to target mRNAs
was initially proposed to occur through interaction with release factors at terminating …
was initially proposed to occur through interaction with release factors at terminating …
Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders
LS Nguyen, HG Kim, JA Rosenfeld… - Human molecular …, 2013 - academic.oup.com
The nonsense-mediated mRNA decay (NMD) pathway functions not only to degrade
transcripts containing premature termination codons (PTC), but also to regulate the …
transcripts containing premature termination codons (PTC), but also to regulate the …
Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression
Nonsense suppression therapy is an approach to treat genetic diseases caused by
nonsense mutations. This therapeutic strategy pharmacologically suppresses translation …
nonsense mutations. This therapeutic strategy pharmacologically suppresses translation …
Role of SMG‐1‐mediated U pf1 phosphorylation in mammalian nonsense‐mediated m RNA decay
A Yamashita - Genes to Cells, 2013 - Wiley Online Library
SMG‐1, a member of the PIKK (phosphoinositide 3‐kinase‐related kinase) family, plays a
critical role in the m RNA quality control system known as nonsense‐mediated m RNA …
critical role in the m RNA quality control system known as nonsense‐mediated m RNA …
[HTML][HTML] When a ribosome encounters a premature termination codon
In mammalian cells, aberrant transcripts harboring a premature termination codon (PTC) can
be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation …
be generated by abnormal or inefficient biogenesis of mRNAs or by somatic mutation …
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity
F Usuki, A Yamashita, T Shiraishi… - Proceedings of the …, 2013 - National Acad Sciences
Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that
eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits …
eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits …
Accounting for noise when clustering biological data
R Sloutsky, N Jimenez, SJ Swamidass… - Briefings in …, 2013 - academic.oup.com
Clustering is a powerful and commonly used technique that organizes and elucidates the
structure of biological data. Clustering data from gene expression, metabolomics and …
structure of biological data. Clustering data from gene expression, metabolomics and …
Genome-wide pathway analysis reveals different signaling pathways between secreted lactoferrin and intracellular delta-lactoferrin
B Kim, S Kang, SJ Kim - PLoS One, 2013 - journals.plos.org
Human lactoferrin (LF) is a multifunctional protein involved in immunomodulation, cellular
growth, and differentiation. In addition to its secreted form (sLF), an alternative form (ΔLF) …
growth, and differentiation. In addition to its secreted form (sLF), an alternative form (ΔLF) …