Synaptic activity initiates biochemical processes that have various outcomes, including the
formation of memories, increases in neuronal survival and the development of chronic pain …

Parental care influences development across mammals. In humans such influences include
effects on phenotypes, such as stress reactivity, which determine individual differences in …

The differentiation of CD8 T cells in response to acute infection results in the acquisition of
hallmark phenotypic effector functions; however, the epigenetic mechanisms that program …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

All important developmental milestones are accomplished during the fetal stage, and
nutrient fluctuation during this stage produces lasting effects on offspring health, so called …

MicroRNAs (MiRNAs) are small non-coding RNAs that regulate their target genes
expression at the post-transcriptional level. As accumulating properties of miR-205 have …

Background DNA methylation is one of the most phylogenetically widespread epigenetic
modifications of genomic DNA. In particular, DNA methylation of transcription units ('gene …

The aberrant methylation of CpG island promoters of selected genes is the prominent
epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant …

Background: Tumor necrosis factor‐α (TNF‐α) plays a central role in the molecular
pathogenesis of periodontal disease. However, the epigenetic regulation attributable to …

Epigenetic regulation can mediate long-lasting changes in gene expression, which makes it
an attractive mechanism for the stable behavioral abnormalities that characterize drug …