[HTML][HTML] Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation
UM Zanger, M Schwab - Pharmacology & therapeutics, 2013 - Elsevier
Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …
Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects
Type 2 diabetes has rapidly emerged as a global health crisis. Because population-level
genetic changes take many generations to occur, this epidemic is almost certainly primarily …
genetic changes take many generations to occur, this epidemic is almost certainly primarily …
Genotyping of CYP2C9 and VKORC1 in the Arabic Population of Al‐Ahsa, Saudi Arabia
AM Alzahrani, G Ragia, H Hanieh… - BioMed research …, 2013 - Wiley Online Library
Polymorphisms in the genes encoding CYP2C9 enzyme and VKORC1 reductase
significantly influence the dose variability of coumarinic oral anticoagulants (COAs) …
significantly influence the dose variability of coumarinic oral anticoagulants (COAs) …
The role of pharmacogenetics in drug disposition and response of oral glucose-lowering drugs
N Van Leeuwen, JJ Swen, HJ Guchelaar… - Clinical …, 2013 - Springer
The primary goal of type 2 diabetes mellitus (T2DM) disease management is improvement of
quality of life and prevention of complications. One way to achieve these goals is improving …
quality of life and prevention of complications. One way to achieve these goals is improving …
Personalized medicine of type 2 diabetes
W Jia - Frontiers of medicine, 2013 - Springer
Type 2 diabetes is characterized by impaired insulin secretion and decreased insulin
sensitivity. It has reached epidemic proportions worldwide and poses a considerable …
sensitivity. It has reached epidemic proportions worldwide and poses a considerable …
The Role of Pharmacogenomics in Diabetes, HIV Infection, and Pain Management
CL Aquilante, YWF Lam - Pharmacogenomics, 2013 - Elsevier
Diabetes mellitus has emerged as a major public health epidemic in the 21st century. Type 2
diabetes is the most prevalent form of diabetes in adults, accounting for 90 to 95% of cases …
diabetes is the most prevalent form of diabetes in adults, accounting for 90 to 95% of cases …
[PDF][PDF] Rambam Maimonides Medical Journal
E Karnieli, GS Harry, R Naphtali - rmmj.org.il
The world is facing an epidemic rise in Diabetes Mellitus (DM) incidence, which is
challenging health funders, health systems, clinicians and patients to understand and …
challenging health funders, health systems, clinicians and patients to understand and …
[PDF][PDF] Polygenic Risk Models Suggest Protective Effects of Lipid Genes on Plasma Glucose, HbA1c and HOMA-IR levels
SJL Bakker, RPF Dullaart, P van der Harst… - Novel Mechanisms for …, 2013 - core.ac.uk
OBJECTIVE: Dyslipidemia is strongly associated with raised glucose levels and its clinical
endpoint of type 2 diabetes (T2D). However, the causal nature of this relationship and the …
endpoint of type 2 diabetes (T2D). However, the causal nature of this relationship and the …
[PDF][PDF] Research Article Genotyping of CYP2C9 and VKORC1 in the Arabic Population of Al-Ahsa, Saudi Arabia
AM Alzahrani, G Ragia, H Hanieh, VG Manolopoulos - 2013 - academia.edu
Polymorphisms in the genes encoding CYP2C9 enzyme and VKORC1 reductase
significantly influence the dose variability of coumarinic oral anticoagulants (COAs) …
significantly influence the dose variability of coumarinic oral anticoagulants (COAs) …