Herpes simplex virus (HSV) evolved an elegant strategy that enables the virus to impact a
large fraction of the human population. The virus replicates at the portal of entry (mouth …

Background Cost-effectiveness studies inform resource allocation, strategy, and policy
development. However, due to their complexity, dependence on assumptions made, and …

Methods: Using data from 3 prospective studies of HIV-1–serodiscordant couples from 7
African countries and standard methods for development of clinical prediction rules, the …

We describe the frequency of and factors associated with disclosure, knowledge of partner's
HIV status, and consistent condom use among 3538 HIV-positive patients attending …

Objective: Effective behavioral HIV prevention is needed for stable HIV-discordant couples
at risk for HIV, especially those without access to biomedical prevention. This analysis …

Background. Daily suppressive therapy with valacyclovir reduces risk of sexual transmission
of herpes simplex virus type 2 (HSV-2) in HSV-2–serodiscordant heterosexual couples by …

Background: For HIV-1-infected women, hormonal contraception prevents unintended
pregnancy, excess maternal morbidity, and vertical HIV-1 transmission. Hormonal …

Abstract Background The Fogarty International Center (FIC) has supported research
capacity development for over twenty years. While the mission of FIC is supporting and …

Plasma HIV-1 RNA set point is an important predictor of HIV-1 disease progression. We
hypothesized that inoculum size and HIV-1 exposure prior to HIV-1 transmission may …

Background. Combination antiretroviral therapy (cART) reduces genital tract human
immunodeficiency virus type 1 (HIV-1) load and reduces the risk of sexual transmission, but …