Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and has a significant impact on
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …

Small molecules interfering with Rac1 activation are considered as potential drugs and are
already studied in animal models. A widely used inhibitor without reported attenuation of …

Shortened action-potential duration (APD) and blunted APD rate adaptation are hallmarks of
chronic atrial fibrillation (cAF). Basal and muscarinic (M)-receptor-activated inward-rectifier …

Atrial fibrillation (AF), the most common sustained arrhythmia associated with substantial
cardiovascular morbidity and mortality with stroke being the most critical complication. Most …

The study of electrophysiological properties of cardiac ion channels with the patch-clamp
technique and the exploration of cardiac cellular Ca2+ handling abnormalities requires …

Atrial fibrillation (AF) is the most frequently-encountered arrhythmia in clinical practice and
constitutes a major cause of cardiac morbidity and mortality. The management of AF remains …

The principal goal of antiarrhythmic therapy in the management of atrial fibrillation (AF) is to
prolong the effective refractory period (ERP), which makes rapid activation of the atria …