When the first edition of this book was published in 1950, it predated the publication of the
double-helical structure of DNA by three years. It is not, therefore, surprizing that nothing of …

Bacterial biofilms are complex communities of cells that are attached to a surface by an
extracellular matrix. Biofilms are an increasing environmental and healthcare issue, causing …

Introduction–reactions of the shikimate pathway 3. Biochemical characteristics of shikimate
pathway enzymes 3.1. 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS) …

The width of the DNA minor groove varies with sequence and can be a major determinant of
DNA shape recognition by proteins. For example, the minor groove within the center of the …

The transcription of many genes, particularly in prokaryotes, is controlled by transcription
factors whose activity can be modulated by controlling their DNA binding affinity …

LysR-type transcriptional regulators (LTTRs) play critical roles in metabolism and constitute
the largest family of bacterial regulators. To understand protein–DNA interactions, atomic …

Precisely measuring the ensemble of conformers that a macromolecule populates in
solution is highly challenging. Thus, it has been difficult to confirm or falsify the predictions of …

A conformationally flexible C3v symmetric N-bridged tripodal amide receptor encapsulates a
tetrameric halide water cluster [X2 (H2O) 2] 2−(X= Cl−/Br−) within its dimeric capsular …

Consistent with their complex lifestyles and rich secondary metabolite profiles, the genomes
of streptomycetes encode a plethora of transcription factors, the vast majority of which are …

HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations
in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA …