Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis

MA Gimbrone Jr, G García-Cardeña - Cardiovascular Pathology, 2013 - Elsevier
The localization of atherosclerotic lesion formation to regions of disturbed blood flow
associated with certain arterial geometries, in humans and experimental animals, suggests …

The UPR in atherosclerosis

AX Zhou, I Tabas - Seminars in immunopathology, 2013 - Springer
Multiple systemic factors and local stressors in the arterial wall can disturb the functions of
endoplasmic reticulum (ER), causing ER stress in endothelial cells (ECs), smooth muscle …

Hypercholesterolemia links hematopoiesis with atherosclerosis

O Soehnlein, FK Swirski - Trends in Endocrinology & Metabolism, 2013 - cell.com
Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …

Tomato extract and the carotenoids lycopene and lutein improve endothelial function and attenuate inflammatory NF-κB signaling in endothelial cells

A Armoza, Y Haim, A Basiri, T Wolak… - Journal of …, 2013 - journals.lww.com
Objectives: In our previous research the antihypertensive properties of lycopene-containing
tomato oleoresin have been revealed. The present study was aimed to assess if oleoresin …

Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other …

M Ouimet - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
The incidence of diseases characterized by a dysregulation of lipid metabolism such as
obesity, diabetes and atherosclerosis is rising at alarming rates, driving research to uncover …

Lactobacillus acidophilus ATCC 4356 attenuates the atherosclerotic progression through modulation of oxidative stress and inflammatory process

L Chen, W Liu, Y Li, S Luo, Q Liu, Y Zhong… - International …, 2013 - Elsevier
The aim of this study was to investigate the effect of Lactobacillus (L.) acidophilus ATCC
4356 on the progression of atherosclerosis in Apoliprotein-E knockout (ApoE−/−) mice and …

Assessing the functional properties of high-density lipoproteins: an emerging concept in cardiovascular research

M Triolo, W Annema, RPF Dullaart… - Biomarkers in …, 2013 - Taylor & Francis
Although plasma concentrations of high-density lipoprotein (HDL) cholesterol correlate
inversely with the incidence of atherosclerotic cardiovascular disease, results from recent …

Apolipoprotein A‐I: Insights from redox proteomics for its role in neurodegeneration

JTR Keeney, AM Swomley, S Förster… - PROTEOMICS …, 2013 - Wiley Online Library
Proteomics has a wide range of applications, including determination of differences in the
proteome in terms of expression and post‐translational protein modifications. Redox …

The effect of oxidized low-density lipoprotein (ox-LDL) on radiation-induced endothelial-to-mesenchymal transition

M Kim, SH Choi, YB Jin, HJ Lee, YH Ji… - … journal of radiation …, 2013 - Taylor & Francis
Purpose: Radiation-induced cardiovascular disease is a potentially severe side-effect of
thoracic radiotherapy treatment. Clinically, this delayed side-effect presents as a form of …

Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells

W Zhang, J An, H Jawadi, DL Siow, JF Lee… - Prostaglandins & other …, 2013 - Elsevier
Abstract Sphingosine-1-phosphate (S1P) regulates a wide array of biological functions in
endothelial cells. We previously showed that S1P receptor subtype 2 (S1P 2) is significantly …