Fingolimod is the first oral disease-modifying therapy approved for relapsing forms of
multiple sclerosis (MS). Following phosphorylation in vivo, the active agent, fingolimod …

Neural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent
brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus …

Recent evidence suggests that astrocytes play an important role in regulating de-and
remyelination in multiple sclerosis. The role of astrocytes is controversial, and both …

Oligodendrocyte precursor cells (OPCs) originate in specific areas of the developing central
nervous system (CNS). Once generated, they migrate towards their destinations where they …

In the past decade, evidence has emerged that there is a variety of bidirectional cell-cell
and/or cellextracellular matrix interactions within the neurovascular unit (NVU), which is …

Astrocytes are the most abundant cell type in the adult central nervous system (CNS), and
their functional diversity in response to injury is now being appreciated. Astrocytes have long …

Astrocytes regulate fundamentally important functions to maintain central nervous system
(CNS) homeostasis. Altered astrocytic function is now recognized as a primary contributing …

Glial cells are non-neuronal components of the central nervous system (CNS). They are
endowed with diverse functions and are provided with tools to detect their own activities and …

Remyelination is disrupted in demyelinating diseases such as multiple sclerosis, but the
underlying pathogenetic mechanisms are unclear. In this study, we employed the murine …

In vitro and in vivo studies on the role of tenascins have shown that the two paradigmatic
glycoproteins of the tenascin family, tenascin-C (TnC) and tenascin-R (TnR) play important …