The in vivo biofilm

T Bjarnsholt, M Alhede, M Alhede… - Trends in …, 2013 - cell.com
Bacteria can grow and proliferate either as single, independent cells or organized in
aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm …

Applying insights from biofilm biology to drug development—can a new approach be developed?

T Bjarnsholt, O Ciofu, S Molin, M Givskov… - Nature reviews Drug …, 2013 - nature.com
Most of the research on bacterial pathogenesis has focused on acute infections, but much
less is known about the pathogenesis of infections caused by bacteria that grow as …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

Host responses in tissue repair and fibrosis

JS Duffield, M Lupher, VJ Thannickal… - Annual Review of …, 2013 - annualreviews.org
Myofibroblasts accumulate in the spaces between organ structures and produce
extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells …

Microanatomy at cellular resolution and spatial order of physiological differentiation in a bacterial biofilm

DO Serra, AM Richter, G Klauck, F Mika, R Hengge - MBio, 2013 - Am Soc Microbiol
Bacterial biofilms are highly structured multicellular communities whose formation involves
flagella and an extracellular matrix of adhesins, amyloid fibers, and exopolysaccharides …

Biofilm-associated infections: antibiotic resistance and novel therapeutic strategies

F Sun, F Qu, Y Ling, P Mao, P Xia, H Chen… - Future …, 2013 - Taylor & Francis
Infections with bacterial or fungal biofilms have emerged as a major public heath concern
because biofilm-growing cells are highly resistant to both antibiotics and host immune …

EWMA document: antimicrobials and non-healing wounds: evidence, controversies and suggestions

F Gottrup, J Apelqvist, T Bjarnsholt… - Journal of wound …, 2013 - magonlinelibrary.com
JOURNAL OF WOUND CARE VOL 22. NO 5. EWMA DOCUMENT 2013 S5 year, 11 of
which more than half are drug-resistant. 12 Infections based on resistant bacteria are …

[HTML][HTML] Complete Genome Sequence of the Cystic Fibrosis Pathogen Achromobacter xylosoxidans NH44784-1996 Complies with Important Pathogenic Phenotypes

TH Jakobsen, MA Hansen, PØ Jensen, L Hansen… - PloS one, 2013 - journals.plos.org
Achromobacter xylosoxidans is an environmental opportunistic pathogen, which infects an
increasing number of immunocompromised patients. In this study we combined genomic …

[HTML][HTML] The Staphylococcus aureus ArlRS Two-Component System Is a Novel Regulator of Agglutination and Pathogenesis

JN Walker, HA Crosby, AR Spaulding… - PLoS …, 2013 - journals.plos.org
Staphylococcus aureus is a prominent bacterial pathogen that is known to agglutinate in the
presence of human plasma to form stable clumps. There is increasing evidence that …

[HTML][HTML] Antimicrobial Efficacy of Two Surface Barrier Discharges with Air Plasma against In Vitro Biofilms

R Matthes, C Bender, R Schlüter, I Koban, R Bussiahn… - PloS one, 2013 - journals.plos.org
The treatment of infected wounds is one possible therapeutic aspect of plasma medicine.
Chronic wounds are often associated with microbial biofilms which limit the efficacy of …