Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

Dendritic cells (DCs) initiate and control immune responses, participate in the maintenance
of immunological tolerance and are pivotal players in the pathogenesis of autoimmunity. In …

Inflammasomes are the central processing units (CPUs) responsible for decoding and
integrating signals of foreignness, damage, danger, and distress released by pathogens …

Background Extracellular adenosine triphosphate (ATP) functions as a novel danger signal
that boosts antitumor immunity and can also directly kill tumor cells. We have previously …

Immunogenic Cell Death (ICD) could represent the keystone in cancer management since
tumor cell death induction is crucial as well as the control of cancer cells revival after …

Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …

Introduction Small cell lung cancer (SCLC) is an aggressive malignancy that although
initially sensitive to chemo-and radiation therapy, inevitably relapses resulting in poor …

The central role of chronic inflammation in the promotion of tumor growth is supported by a
broad range of experimental and clinical evidence. However, the molecular mechanisms …

Therapeutic vaccination is regarded as a promising strategy against multiple hematological
malignancies including lymphoma. However, this approach alone possesses limited …