Polyprodrug amphiphiles: hierarchical assemblies for shape-regulated cellular internalization, trafficking, and drug delivery

X Hu, J Hu, J Tian, Z Ge, G Zhang… - Journal of the American …, 2013 - ACS Publications
Solution self-assembly of block copolymers (BCPs) typically generates spheres, rods, and
vesicles. The reproducible bottom-up fabrication of stable planar nanostructures remains …

Synthetic approaches to RBC mimicry and oxygen carrier systems

CL Modery-Pawlowski, LL Tian, V Pan… - …, 2013 - ACS Publications
Whole blood or red blood cell (RBC) transfusions are highly significant, clinically, for blood
replacement therapies in traumatic injuries, presurgical conditions, and anemias. However …

In vitro and in vivo hemostatic capabilities of a functionally integrated platelet-mimetic liposomal nanoconstruct

CL Modery-Pawlowski, LL Tian, M Ravikumar… - Biomaterials, 2013 - Elsevier
There is significant clinical interest in synthetic platelet substitutes that can mimic platelet's
hemostastic functionalities while allowing scale-up, minimal biological contamination, and …

A platelet-inspired paradigm for nanomedicine targeted to multiple diseases

CL Modery-Pawlowski, HH Kuo, WM Baldwin 3rd… - …, 2013 - Taylor & Francis
Platelets are megakaryocyte-derived anucleated cells found in the blood. They are mainly
responsible for rendering hemostasis or clotting to prevent bleeding complications …

Shear‐responsive platelet mimetics for targeted drug delivery

N Korin, M Kanapathipillai… - Israel Journal of …, 2013 - Wiley Online Library
Most targeted drug delivery approaches utilize molecular targets or regional variations in
chemical or structural properties of the tissue microenvironment to localize drug at disease …

[PDF][PDF] Nanoparticle biointerfacing via platelet membrane cloaking

C Hu, RH Fang, J Copp, BT Luk, L Zhang - Nat. Nanotechnol, 2013 - researchgate.net
Development of functional nanoparticles can be encumbered by unanticipated material
properties and biological events, which can negatively impact nanoparticle effectiveness in …