Mouse models with cell-specific deletion of the estrogen receptor (ER) α, the androgen
receptor (AR) or the receptor activator of nuclear factor κB ligand (RANKL), as well as …

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult
bone remodeling. They also participate in the pathogenesis of various bone disorders …

Although it has long been recognized that inflammation, a consequence of immune‐driven
processes, significantly impacts bone turnover, the degree of centralization of skeletal and …

Background. Although data from rodent systems are extremely useful in providing insights
into possible mechanisms of age-related bone loss, concepts evolving from animal models …

Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone
and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin …

Sažetak Bone and immune system are functionally interconnected. Immune and bone cells
derive from same progenitors in the bone marrow, they share a common microenvironment …

In the last two decades, numerous scientists have highlighted the interactions between bone
and immune cells as well as their overlapping regulatory mechanisms. For example …

In the last years, new evidences of the relationship between immune system and bone have
been accumulated both in animal models and in humans affected by bone disease, such as …

In a phase 2 study, continued denosumab treatment for up to 8 years was associated with
continued gains in bone mineral density and persistent reductions in bone turnover markers …

Estrogen therapy and hormone therapy are effective options for the prevention and
treatment of osteoporosis, although because of their significant side effect profile, long term …