Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

The CD8+ memory T cell population is heterogeneous, and it is unclear which subset (s)
optimally mediate the central goal of the immune system—protection against infection. Here …

T cell migration is crucial for an effective adaptive immune response to invading pathogens.
Naive and memory T cells encounter pathogen antigens, become activated, and differentiate …

CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the
generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells …

Rapid boosting of memory CD8+ T cells (TM) is essential in cancer immunotherapy and the
control of certain infectious diseases. However, effector T cells (TE) are a barrier to booster …

Vaccines, arguably the single most important intervention in improving human health, have
exploited the phenomenon of immunological memory. The elicitation of memory T cells is …

A fundamental property of the adaptive immune system is the ability to generate antigen-
specific memory, which protects against repeated infections with the same pathogens and …

Clinical evidence for a more active immune response in humans compared with our closest
hominid relative, the chimpanzee, includes the progression of HIV infection to AIDS …

The fate of F oxp3+ regulatory T (T reg) cells responding during autoimmunity is not well
defined. We observed a marked elevation in KLRG 1+(where KLRG1 stands for killer cell …

CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of
immune responses in secondary lymphoid tissue. It has also been reported that CCR7 …