Memory T cell subsets, migration patterns, and tissue residence

SN Mueller, T Gebhardt, FR Carbone… - Annual review of …, 2013 - annualreviews.org
Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

[PDF][PDF] Effector-like CD8+ T cells in the memory population mediate potent protective immunity

JA Olson, C McDonald-Hyman, SC Jameson… - Immunity, 2013 - cell.com
The CD8+ memory T cell population is heterogeneous, and it is unclear which subset (s)
optimally mediate the central goal of the immune system—protection against infection. Here …

Location, location, location: the impact of migratory heterogeneity on T cell function

BJG Baaten, AM Cooper, SL Swain… - Frontiers in …, 2013 - frontiersin.org
T cell migration is crucial for an effective adaptive immune response to invading pathogens.
Naive and memory T cells encounter pathogen antigens, become activated, and differentiate …

Id2 influences differentiation of killer cell lectin-like receptor G1hi short-lived CD8+ effector T cells

J Knell, JA Best, NA Lind, E Yang… - The Journal of …, 2013 - journals.aai.org
CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the
generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells …

Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T-cell recall responses

L Zhang, BW Bridle, L Chen, J Pol… - Blood, The Journal …, 2013 - ashpublications.org
Rapid boosting of memory CD8+ T cells (TM) is essential in cancer immunotherapy and the
control of certain infectious diseases. However, effector T cells (TE) are a barrier to booster …

Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development

S Kurtulus, P Tripathi, DA Hildeman - Frontiers in immunology, 2013 - frontiersin.org
Vaccines, arguably the single most important intervention in improving human health, have
exploited the phenomenon of immunological memory. The elicitation of memory T cells is …

Decisions on the road to memory

D Amsen, RA Backer, C Helbig - … between innate and adaptive immunity IV, 2013 - Springer
A fundamental property of the adaptive immune system is the ability to generate antigen-
specific memory, which protects against repeated infections with the same pathogens and …

Enhanced T cell function in a mouse model of human glycosylation

G Buchlis, P Odorizzi, PC Soto, OMT Pearce… - The Journal of …, 2013 - journals.aai.org
Clinical evidence for a more active immune response in humans compared with our closest
hominid relative, the chimpanzee, includes the progression of HIV infection to AIDS …

Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis

S Tauro, P Nguyen, B Li… - European journal of …, 2013 - Wiley Online Library
The fate of F oxp3+ regulatory T (T reg) cells responding during autoimmunity is not well
defined. We observed a marked elevation in KLRG 1+(where KLRG1 stands for killer cell …

[HTML][HTML] CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells

B Choi, HC Lim, ES Lee, AKMM Anower, S Sohn - Immunobiology, 2013 - Elsevier
CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of
immune responses in secondary lymphoid tissue. It has also been reported that CCR7 …