Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA
methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under …

The prognostic significance of O 6-methylguanine-DNA methyltransferase (MGMT) promoter
methylation on Glioblastoma multiforme (GBM) remains controversial. A meta-analysis of …

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best
clinical approach for treatment is based on administration of temozolomide (TMZ) in …

Abstract Purpose: O6-methylguanine-DNA-methyltransferase (MGMT) is a DNA repair
protein removing mutagenic and cytotoxic adducts from O6-guanine in DNA. Approximately …

Pilocytic astrocytomas (PAs) are the most common brain tumors in pediatric patients and can
cause significant morbidity, including chronic neurological deficiencies. They are …

Initiation and progression of human caner not only depends on genetic alterations but also
on epigenetic changes such as DNA methylation and histone modifications. Aberrant DNA …

Epigenetic aberrations offer dynamic and reversible targets for cancer therapy; increasingly,
alteration via overexpression, mutation, or rearrangement is found in genes that control the …

Molecular classification of colorectal cancer (CRC) is currently based on microsatellite
instability (MSI), KRAS or BRAF mutation and, occasionally, chromosomal instability (CIN) …

Recent advances in modern molecular technologies allow for the examination and
measurement of cancer-related genomic changes. The number of molecular tests for …