The incidence of fungal infections has increased significantly, so contributing to morbidity
and mortality. This is caused by an increase in antimicrobial resistance and the restricted …

Candida commonly adheres to implanted medical devices, growing as a resilient biofilm
capable of withstanding extraordinarily high antifungal concentrations. As currently available …

Highlights•Fungal infections affect an expanding population of immunosuppressed
patients.•The current arsenal of antifungal drugs is exceedingly limited.•Toxicity problems …

ABSTRACT The Gram-positive bacterium Enterococcus faecalis and the fungus Candida
albicans are both found as commensals in many of the same niches of the human body …

Introduction: Targeting pathogenetic mechanisms, rather than essential processes,
represents a very attractive alternative for the development of new antibiotics. This may be …

Background and Aims Candida species, especially Candida albicans, are major fungal
pathogens of humans that are capable of causing superficial mucosal infections and …

Candida albicans is the most common etiologic agent of systemic fungal infections with
unacceptably high mortality rates. The existing arsenal of antifungal drugs is very limited and …

Candida spp. are part of the natural human microbiota, but they also represent important
opportunistic human pathogens. Biofilm-associated Candida albicans infections are …

The widespread use of intravascular devices, such as central venous and hemodialysis
catheters, in the past 2 decades has paralleled the increasing incidence of catheter-related …

This study presents the first global transcriptional profiling and phenotypic characterization
of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight …