[PDF][PDF] Drug-excipient behavior in polymeric amorphous solid dispersions.

SB Teja, SP Patil, G Shete, S Patel… - Journal of Excipients …, 2013 - jefc.scholasticahq.com
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility
and oral bioavailability. However, they lack physical and/or chemical stability. One of the …

Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled …

N Shah, RM Iyer, HJ Mair, D Choi, H Tian… - Journal of …, 2013 - Elsevier
The present work deals with improving the solubility of vemurafenib, a practically insoluble
drug, by converting it into an amorphous-solid dispersion using a solventcontrolled …

Molecular dynamics, physical stability and solubility advantage from amorphous indapamide drug

Z Wojnarowska, K Grzybowska, L Hawelek… - Molecular …, 2013 - ACS Publications
This study for the first time investigates physicochemical properties of amorphous
indapamide drug (IND), which is a known diuretic agent commonly used in the treatment of …

Microstructure of an immiscible polymer blend and its stabilization effect on amorphous solid dispersions

Z Yang, K Nollenberger, J Albers… - Molecular …, 2013 - ACS Publications
This study proposes use of the phase separation of immiscible polymer blends as a
formulation approach to improve the stabilization and solubilization of amorphous molecular …

Stabilisation of amorphous drugs under high humidity using pharmaceutical thin films

YC Ng, Z Yang, WJ McAuley, S Qi - European Journal of Pharmaceutics …, 2013 - Elsevier
In this study, the stabilization effects of three polymers on four model drugs (felodipine,
fenofibrate, carbamazepine, and celecoxib) under saturated humidity were investigated …

Molecular dynamics in liquid and glassy states of non-steroidal anti-inflammatory drug: ketoprofen

U Sailaja, MS Thayyil, NSK Kumar… - European Journal of …, 2013 - Elsevier
Ketoprofen is a well known nonsteroidal anti-inflammatory drug (NSAID) with analgesic and
antipyretic effects. It acts by inhibiting the body's production of prostaglandin. The molecular …

[图书][B] Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, Volume 2

S Dumitriu, V Popa - 2013 - books.google.com
The third edition of a bestseller, this substantially expanded reference, now in two volumes,
presents the latest polymer developments and most up-to-date applications of polymeric …

Ternary dispersions to enhance solubility of poorly water soluble antioxidants

M Kakran, NG Sahoo, YW Tan, L Li - Colloids and Surfaces A …, 2013 - Elsevier
The main aim of this study was to enhance the solubility and dissolution rate of the two
poorly water-soluble antioxidants, curcumin (CUR) and hesperetin (HSP). Binary …

[引用][C] 非晶态给药体系的形成机制与制备工艺的研究进展

王杏林, 王频, 尹东东 - 中国新药杂志, 2013