Microparticles (MPs) represent a heterogeneous population of submicronic vesicles that are
released in response to cell activation or apoptosis. MPs harbor a large repertoire of cell …

Tissue factor (TF) is a transmembrane cofactor that binds and promotes the catalytic activity
of factor (F) VII a. The TF/VII a complex activates FX by limited proteolysis to initiate blood …

Achieving hemostasis following vascular injury requires the rapid accumulation of platelets
and fibrin. Here we used a combination of confocal intravital imaging, genetically …

Although the incidence of ovarian cancer is low (ie, less than 5% in European countries), it is
the most lethal gynecologic malignancy and typically has a poor prognosis. To ensure …

The central role of platelets in the formation of the primary haemostatic plug as well as in the
development of arterial thrombosis is well defined. In general, the molecular events …

Objective. To develop and evaluate a multicolour flow cytometry method for analysis of
microparticles (MPs) in fresh whole blood without any centrifugation steps or …

Interaction of activated platelets and leukocytes (mainly neutrophils) on the activated
endothelium mediates thrombosis and vascular inflammation. 1, 2 During thrombus …

Extracellular vesicles (EVs), including exosomes, act as biological effectors and as carriers
of oncogenic signatures in human cancer. The molecular composition and accessibility of …

The role of tissue factor (TF)-containing microparticles in clot propagation has been
established, but the ability of circulating microparticles to initiate coagulation has been …

Hemostasis is an intrinsic property of the vascular system that prevents blood loss during
accidental disruption of the vessel wall. Late mechanisms of hemostasis comprise vessel …