Epigenetic modifications, including changes in DNA methylation, lead to altered gene
expression and thus may underlie epileptogenesis via induction of permanent changes in …

Experimental research over the past decade has supported the critical role of astrocytes
activated by different types of injury and the pathophysiological processes that underlie the …

Adenosine inhibits epileptic episodes by interacting with G-protein-coupled receptors. This
study examined the mechanism by which the inhibitory effect of adenosine becomes …

Experimental models of epilepsy, including pentylenetetrazol (PTZ) chemical kindling, are
very important in studying the pathophysiology of epilepsy. The aim of the present study was …

Background Adenosine is an endogenous neuromodulator in both the peripheral and
central nervous systems. Adenosine inhibits pain signals by hyperpolarizing neuronal …

A doença de Alzheimer é uma desordem neurodegenerativa progressiva que vem
crescendo em função do aumento populacional e do aumento da expectativa de vida e …

Gostaria de agradecer aos meus orientadores, Dr. ª Paula Agostinho e Dr. Ângelo Tomé,
pelo empenho e disponibilidade, pela fé e por toda a motivação mostrada durante todo o …

Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the
brain, are mutually promoting, and play a role in the onset and progression of …

The activation of adenosine A 2A receptors (A 2A R) is mediated by adenosine that can be
originated from the extracellular catabolism of released ATP. Ecto-5'-nucleotidase (e-5'N) …

Ovaj rad je urađen u Laboratoriji za Neurohemiju, Odeljenja za neurobiologiju, Instituta za
biološka istraživanja „Siniša Stanković “, Univerziteta u Beogradu u okviru projekta „Ćelijska …