BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses
Histone acetylation regulates activation and repression of multiple inflammatory genes
known to play critical roles in chronic inflammatory diseases. However, proteins responsible …
known to play critical roles in chronic inflammatory diseases. However, proteins responsible …
[HTML][HTML] Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor
H Sakaki, M Tsukimoto, H Harada, Y Moriyama… - PloS one, 2013 - journals.plos.org
It is important to understand the mechanisms that regulate macrophage activation to
establish novel therapies for inflammatory diseases, such as sepsis; a systemic inflammatory …
establish novel therapies for inflammatory diseases, such as sepsis; a systemic inflammatory …
Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors
L Heinbockel, S Sánchez-Gómez… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Bacterial infections are known to cause severe health-threatening conditions, including
sepsis. All attempts to get this disease under control failed in the past, and especially in …
sepsis. All attempts to get this disease under control failed in the past, and especially in …
MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock
Septic shock is one of leading causes of morbidity and mortality in hospital patients.
However, genetic factors predisposing to septic shock are not fully understood. Our previous …
However, genetic factors predisposing to septic shock are not fully understood. Our previous …
Bis-N-norgliovictin, a small-molecule compound from marine fungus, inhibits LPS-induced inflammation in macrophages and improves survival in sepsis
Y Song, H Dou, W Gong, X Liu, Z Yu, E Li, R Tan… - European journal of …, 2013 - Elsevier
Sepsis is a highly lethal disorder characterized by systemic inflammation, and Toll-like
receptor 4 (TLR4) in macrophages plays a crucial role in modulating innate immune …
receptor 4 (TLR4) in macrophages plays a crucial role in modulating innate immune …
Mollugin inhibits the inflammatory response in lipopolysaccharide-stimulated RAW264. 7 macrophages by blocking the Janus kinase-signal transducers and …
ZG Zhu, H Jin, PJ Yu, YX Tian, JJ Zhang… - Biological and …, 2013 - jstage.jst.go.jp
Mollugin, a kind of naphthohydroquinone, is a major constituent isolated from Rubia
cordifolia L. and demonstrated to possess anti-inflammatory activity in recent reports …
cordifolia L. and demonstrated to possess anti-inflammatory activity in recent reports …
[HTML][HTML] Anti-tumor necrosis factor VNAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock
R Bojalil, MT Mata-González, F Sánchez-Muñoz… - BMC immunology, 2013 - Springer
Background In sepsis, tumor necrosis factor (TNF) is the key factor triggering respiratory
burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal …
burst, tissue injury and disseminated coagulation. Anti-TNF strategies based on monoclonal …
The anti-inflammatory effect of Lithospermum Erythrorhizon on lipopolysaccharide-induced inflammatory response in RAW 264.7 cells
SB Choi, GS Bae, IJ Jo, KC Park, SH Seo… - The Korea Journal of …, 2013 - koreascience.kr
Objective: Lithospermum Erythrorhizon (LE) has been used as an anti-bacterial and anti-
inflammatory agent. However, it is unclear that LE aqueous extract could show the anti …
inflammatory agent. However, it is unclear that LE aqueous extract could show the anti …
Etanercept-can it be used in the treatment of endotoxemia?
Araştırmanın amacı endotoksemide etanersept uygulamasının kan sitokinler, fibrinojen,
antitrombin, 13, 14-dihidro-15-keto prostaglandin F2α ve biyokimyasal parametrelere …
antitrombin, 13, 14-dihidro-15-keto prostaglandin F2α ve biyokimyasal parametrelere …
[PDF][PDF] Etanersept-Endotoksemi Tedavisinde Kullanılabilir mi?
Araştırmanın amacı endotoksemide etanersept uygulamasının kan sitokinler, fibrinojen,
antitrombin, 13, 14-dihidro-15-keto prostaglandin F2α ve biyokimyasal parametrelere …
antitrombin, 13, 14-dihidro-15-keto prostaglandin F2α ve biyokimyasal parametrelere …