Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases
Calcium dependent signaling is highly regulated in cardiomyocytes and determines the
force of cardiac muscle contraction. The cardiac ryanodine receptors (RyR2) play important …
force of cardiac muscle contraction. The cardiac ryanodine receptors (RyR2) play important …
[HTML][HTML] Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling
In cardiac muscle, a number of posttranslational protein modifications can alter the function
of the Ca2+ release channel of the sarcoplasmic reticulum (SR), also known as the …
of the Ca2+ release channel of the sarcoplasmic reticulum (SR), also known as the …
Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization
Objectives: This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …
(AF). Background: JPH2 is believed to have an important role in sarcoplasmic reticulum (SR) …
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle
DA Gutierrez, M Fernandez-Tenorio… - Cardiovascular …, 2013 - academic.oup.com
Aims During β-adrenergic receptor (β-AR) stimulation, phosphorylation of cardiomyocyte
ryanodine receptors by protein kinases may contribute to an increased diastolic Ca2+ spark …
ryanodine receptors by protein kinases may contribute to an increased diastolic Ca2+ spark …
Imaging atrial arrhythmic intracellular calcium in intact heart
W Xie, G Santulli, X Guo, M Gao, BX Chen… - Journal of molecular and …, 2013 - Elsevier
Abnormalities in intracellular Ca 2+ signaling have been proposed to play an essential role
in the pathophysiology of atrial arrhythmias. However, a direct observation of intracellular Ca …
in the pathophysiology of atrial arrhythmias. However, a direct observation of intracellular Ca …
New directions in antiarrhythmic drug therapy for atrial fibrillation
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and has a significant impact on
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …
morbidity and mortality. Current antiarrhythmic drugs for AF suffer from limited safety and …
Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2‐P2328S hearts
Aim R y R 2 mutations are associated with catecholaminergic polymorphic tachycardia, a
condition characterized by ventricular and atrial arrhythmias. The present experiments …
condition characterized by ventricular and atrial arrhythmias. The present experiments …
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy
BACKGROUND: Ventricular tachycardia (VT) is the second most common cause of death in
patients with Duchenne muscular dystrophy (DMD). Recent studies have implicated …
patients with Duchenne muscular dystrophy (DMD). Recent studies have implicated …
Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias
AW Trafford, JD Clarke, MA Richards… - Cardiovascular …, 2013 - academic.oup.com
The atria contribute 25% to ventricular stroke volume and are the site of the commonest
cardiac arrhythmia, atrial fibrillation (AF). The initiation of contraction in the atria is similar to …
cardiac arrhythmia, atrial fibrillation (AF). The initiation of contraction in the atria is similar to …
Electrical storm: recent pathophysiological insights and therapeutic consequences
The implantable cardioverter-defibrillator significantly improves survival in patients with
malignant ventricular arrhythmias but does not target the underlying pathological substrate …
malignant ventricular arrhythmias but does not target the underlying pathological substrate …