50 years of hurdles and hope in anxiolytic drug discovery
Anxiety disorders are the most prevalent group of psychiatric diseases, and have high
personal and societal costs. The search for novel pharmacological treatments for these …
personal and societal costs. The search for novel pharmacological treatments for these …
Neurogenesis along the septo-temporal axis of the hippocampus: are depression and the action of antidepressants region-specific?
In recent years, both major depression and antidepressant therapy have been linked to adult
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …
hippocampal neurogenesis. The hippocampus is not a homogeneous brain area, and a …
[HTML][HTML] Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in …
Vortioxetine (Lu AA21004) is an investigational novel antidepressant with multimodal activity
that functions as a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial …
that functions as a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial …
Mechanisms of antidepressant resistance
Depression is one of the most frequent and severe mental disorder. Since the discovery of
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …
Genetics of attention-deficit/hyperactivity disorder: current findings and future directions
GC Akutagava-Martins, A Salatino-Oliveira… - Expert review of …, 2013 - Taylor & Francis
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder affecting
5.29% of children worldwide. It presents a heterogeneous clinical expression, and both …
5.29% of children worldwide. It presents a heterogeneous clinical expression, and both …
Hippocampal neurogenesis: a biomarker for depression or antidepressant effects? Methodological considerations and perspectives for future research
Whereas animal models of depression are associated with decreased adult hippocampal
neurogenesis, antidepressant treatments, including pharmacotherapy but also …
neurogenesis, antidepressant treatments, including pharmacotherapy but also …
[HTML][HTML] Antidepressant activity: contribution of brain microdialysis in knock-out mice to the understanding of BDNF/5-HT transporter/5-HT autoreceptor interactions
AM Gardier - Frontiers in pharmacology, 2013 - frontiersin.org
Why antidepressants vary in terms of efficacy is currently unclear. Despite the leadership of
selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise …
selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise …
维持性血液透析患者抑郁及焦虑障碍的相关因素分析
张奡， 周燕妮， 雷天香， 汤水福 - 广州医学院学报, 2013 - cqvip.com
目的: 了解维持性血液透析患者抑郁及焦虑障碍的发病率及影响因素. 方法: 选取2012 年1
月至2012 年4 月在广州中医药大学附属第一医院肾内科血液透析中心维持性血液透析患者95 …
月至2012 年4 月在广州中医药大学附属第一医院肾内科血液透析中心维持性血液透析患者95 …