Adult mesenchymal stem cells secrete a variety of angiogenic cytokines and growth factors,
so we proposed that these paracrine mechanisms may be used to promote vascularization …

Human induced pluripotent stem (iPS) cells are a promising source of autologous
cardiomyocytes to repair and regenerate myocardium for treatment of heart disease. In this …

The promise of stem cells to repair the heart after damage or heart attack has not been
realized because most such cells are lost after transplantation. A new approach is to grow …

The regulation of heart growth through the interaction of cell types, matrix molecules, and
mechanical cues is poorly understood, yet is necessary for the heart to reach its proper size …

The heart is considered a predominantly post-mitotic organ with a regeneration rate of
cardiac myocytes of 1% per year or less. 1 Loss of cardiac myocytes is therefore essentially …