The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Ischemic stroke continues to be one of the most challenging diseases in translational
neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Despite ongoing advances in stroke imaging and treatment, ischemic and hemorrhagic
stroke continue to debilitate patients with devastating outcomes at both the personal and …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …

Investigations of (sub-) acute ischaemic stroke (IS) employing quantitative
electroencephalographic (QEEG) methods, in concert with other assessments, are reviewed …

Ischaemic stroke is one of the leading causes of death and disability worldwide, and
intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia …

The migration of polymorphonuclear granulocytes (PMN) into the brain parenchyma and
release of their abundant proteases are considered the main causes of neuronal cell death …