Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems

JC Kraft, JP Freeling, Z Wang, RJY Ho - Journal of pharmaceutical …, 2014 - Elsevier
Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …

Nanoparticles and the mononuclear phagocyte system: pharmacokinetics and applications for inflammatory diseases

G Song, JS Petschauer, AJ Madden… - Current rheumatology …, 2014 - ingentaconnect.com
Nanoparticles (NPs) provide several advantages over the small molecule drugs including
prolonged circulation time and enhanced delivery to targeted sites. Once a NP enters the …

PEG-graft density controls polymeric nanoparticle micelle stability

J Logie, SC Owen, CK McLaughlin… - Chemistry of …, 2014 - ACS Publications
Polymeric nanoparticle micelles typically comprise amphiphilic block copolymers, having a
hydrophobic core that is useful for chemotherapeutic encapsulation, and a hydrophilic …

Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles

Y Liu, Y Hu, L Huang - Biomaterials, 2014 - Elsevier
The pharmacokinetics (PK) and biodistribution of nanoparticles (NPs) are controlled by a
complex array of interrelated, physicochemical and biological factors of NPs. The lipid …

Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles

Y Klapper, OA Hamad, Y Teramura, G Leneweit… - Biomaterials, 2014 - Elsevier
Liposomes are becoming increasingly important as drug delivery systems, to target a drug to
specific cells and tissues and thereby protecting the recipient from toxic effects of the …

[HTML][HTML] Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes

P Sukthankar, LA Avila, SK Whitaker, T Iwamoto… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Branched amphiphilic peptide capsules (BAPCs) are peptide nano-spheres comprised of
equimolar proportions of two branched peptide sequences bis (FLIVI)-K-KKKK and bis …

Nanomaterials for targeted drug delivery to cancer stem cells

A Orza, D Casciano, A Biris - Drug metabolism reviews, 2014 - Taylor & Francis
Recent developments in cancer biology have identified the existence of a sub-poplulation of
cells–cancer stem cells (CSC) that are resistant to most traditional therapies (eg …

Differential binding of plasma proteins by liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the bilayer

NR Kuznetsova, EL Vodovozova - Biochemistry (Moscow), 2014 - Springer
Immediately upon contact with blood, nanosized drug delivery systems become coated with
a so-called protein corona. The quantitative and qualitative composition of the corona …

The ultrasound contrast imaging properties of lipid microbubbles loaded with urokinase in dog livers and their thrombolytic effects when combined with low-frequency …

ST Ren, XN Kang, YR Liao, W Wang, H Ai… - Journal of thrombosis …, 2014 - Springer
A new microbubble loaded with urokinase (uPA-MB) was explored in a previous study.
However, its zeta potential and ultrasound contrast imaging properties and its thrombolytic …

Schede filosofiche

G Sasso - La Cultura, 2014 - rivisteweb.it
188 far non essere quel che è, occorrerebbe escludere la possibilità che, negate da n, le
sillabe che gli tengono dietro e formano la parola «niente» avessero, nella realtà del …