Selective antigen‐specific CD4+ T‐cell, but not CD8+ T‐ or B‐cell, tolerance corrupts cancer immunotherapy
AE Snook, MS Magee, S Schulz… - European Journal of …, 2014 - Wiley Online Library
Self‐tolerance, presumably through lineage‐unbiased elimination of self‐antigen‐specific
lymphocytes (CD4+ T, CD8+ T, and B cells), creates a formidable barrier to cancer …
lymphocytes (CD4+ T, CD8+ T, and B cells), creates a formidable barrier to cancer …
Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C
M Witek, ES Blomain, MS Magee, B Xiang… - International Journal of …, 2014 - Elsevier
Purpose Radiation therapy (RT) is thought to produce clinical responses in cancer patients,
not only through direct toxicity to cancer cells and supporting tumor stroma cells, but also …
not only through direct toxicity to cancer cells and supporting tumor stroma cells, but also …
[HTML][HTML] GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer
GP Marszalowicz, AE Snook, MS Magee, D Merlino… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The emergence of targeted cancer therapy has been limited by the paucity of determinants
which are tumor-specific and generally associated with disease, and have cell dynamics …
which are tumor-specific and generally associated with disease, and have cell dynamics …
Adenovirus-based vectors for the development of prophylactic and therapeutic vaccines
Emerging and reemerging infectious diseases as well as cancer pose great global health
impacts on the society. Vaccines have emerged as effective treatments to prevent or reduce …
impacts on the society. Vaccines have emerged as effective treatments to prevent or reduce …
[HTML][HTML] Self-tolerance eliminates CD4+ T, but not CD8+ T or B, cells corrupting cancer immunotherapy
AE Snook, MS Magee, S Schulz… - European journal of …, 2014 - ncbi.nlm.nih.gov
Self-tolerance, presumably through elimination of all lineages of self antigen-specific
lymphocytes (CD4+ T, CD8+ T and B cells), creates a formidable barrier to cancer …
lymphocytes (CD4+ T, CD8+ T and B cells), creates a formidable barrier to cancer …
Could targeting T-helper cells aid the development of effective cancer vaccines?
AE Snook - Immunotherapy, 2014 - Taylor & Francis
Background Immunotherapy was one of the first treatment forms explored for cancer,
beginning with Coley's toxins in the late 1800s [Citation 1], yet it has remained a field largely …
beginning with Coley's toxins in the late 1800s [Citation 1], yet it has remained a field largely …