NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Protein–protein docking is attracting increasing attention in drug discovery research
targeting protein–protein interactions, owing to its potential in predicting protein–protein …

Protein–protein interactions are fundamental to many biological processes. Experimental
screens have identified tens of thousands of interactions, and structural biology has …

Intracellular recognition of non‐self and also self‐nucleic acids can result in the initiation of
potent pro‐inflammatory and antiviral cytokine responses. Most recently, cGAS was shown …

Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome
biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N …

The generation of [4Fe-4S] clusters in mitochondria critically depends, in both yeast and
human cells, on two A-type ISC proteins (in mammals named ISCA1 and ISCA2), which …

The majority of the eukaryotic genome is transcribed, generating a significant number of
long intergenic noncoding RNAs (lincRNAs). Although lincRNAs represent the most poorly …

Computational prediction of cancer associated SNPs from the large pool of SNP dataset is
now being used as a tool for detecting the probable oncogenes, which are further examined …

Bacteria surround their cytoplasmic membrane with an essential, stress-bearing
peptidoglycan (PG) layer. Growing and dividing cells expand their PG layer by using …

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely
on antibodies as part of their adaptive immune system. They produce the immunoglobulin …