Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional
gene silencing by miRNAs are potential environmental modulators of skeletal muscle …

A marked increase in the frequency of obesity at the population level has resulted in an
increasing number of obese women entering pregnancy. The increasing realization of the …

Microvascular abnormalities, both in function and structure, lead to impaired tissue perfusion
that may affect multiple tissues and organs and seem to be involved in target-organ damage …

Postmenopausal women are prone to develop obesity and insulin resistance, which might
be related to skeletal muscle mitochondrial dysfunction. In a rat model of ovariectomy (OVX) …

This study investigated the influence of three high-fat diets (HFDs), differing in the
percentage of total calories from saturated fat (SF)(6%, 12%, 24%) but identical in total fat …

Type 2 diabetes, characterized by hyperglycemia and hyperlipidemia, is a metabolic
disease resulting from defects in both insulin secretion and insulin resistance. Recently …

Introduction and hypothesis Diabetes mellitus (DM) during pregnancy is associated with
high levels of urinary incontinence (UI) and pelvic floor muscle dysfunction. Mild DM can …

Background: Prenatal growth restraint is associated with increased oxidative stress-as
judged by mitochondrial dysfunction-in pregnancies complicated by preeclampsia or …

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) play a critical role during
vascular remodelling, in both health and disease. Impaired MMP regulation is associated …

Background SIRT3 is an important regulator in cell metabolism, and recent studies have
shown that it may be involved in the pharmacological effects of metformin. However, the …