Peptides containing β-amino acid patterns: challenges and successes in medicinal chemistry
The construction of bioactive peptides using β-amino acid-containing sequence patterns is a
very promising strategy to obtain analogues that exhibit properties of high interest for …
very promising strategy to obtain analogues that exhibit properties of high interest for …
The improved blood–brain barrier permeability of endomorphin-1 using the cell-penetrating peptide synB3 with three different linkages
H Liu, W Zhang, L Ma, L Fan, F Gao, J Ni… - International journal of …, 2014 - Elsevier
Endomorphins, although they have high analgesic activity and few undesirable side effects,
are not in clinical use because of the blood–brain barrier (BBB). One promising solution is to …
are not in clinical use because of the blood–brain barrier (BBB). One promising solution is to …
Modeling of peptaibol analogues incorporating nonpolar α, α-dialkyl glycines shows improved α-helical preorganization and spontaneous membrane permeation
TG Castro, NM Micaelo - The Journal of Physical Chemistry B, 2014 - ACS Publications
In this study, we investigate the effect of nine noncanonical α, α-dialkyl glycines on the
structure, dynamics, and membrane permeation properties of a small peptaibol, peptaibolin …
structure, dynamics, and membrane permeation properties of a small peptaibol, peptaibolin …
Conformational and thermodynamic properties of non-canonical α, α-dialkyl glycines in the peptaibol alamethicin: Molecular dynamics studies
TG Castro, NM Micaelo - The Journal of Physical Chemistry B, 2014 - ACS Publications
In this work, we investigate the structure, dynamic and thermodynamic properties of
noncanonical disubstituted amino acids (α, α-dialkyl glycines), also known as non-natural …
noncanonical disubstituted amino acids (α, α-dialkyl glycines), also known as non-natural …
[PDF][PDF] Synteza peptydomimetyków tryptofanu w reakcji Picteta-Spenglera chiralnych α-aminoaldehydów z pochodnymi β2-lub β3-homo-tryptofanu
M Słupska - 2014 - repozytorium.uw.edu.pl
Białka są wszechobecne w świecie żywym i są niezbędne dla funkcjonowania w zasadzie
każdego znanego organizmu Page 1 Marta Słupska SYNTEZA PEPTYDOMIMETYKÓW …
każdego znanego organizmu Page 1 Marta Słupska SYNTEZA PEPTYDOMIMETYKÓW …