The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …

Autoimmune diseases (ADs) are featured by body′ s immune responses being directed
towards its own specific target organs or multiple organ systems, causing persistent …

Epigenetic markers such as DNA methylation and histone modifications around promoter
regions modify chromatin structure and regulate expression of downstream genes. In fact …

It is generally believed that some inflammatory antigens can recognize Toll-like receptors on
synovial fibroblasts (SFs) and then activate downstream signals, leading to the formation of …

Microribonucleic acids, best known as microRNAs or miRNAs, are small, non-coding RNAs
with important regulatory roles in eukaryotic cells. Here, I present a broad review on highly …

Background MicroRNAs (miRNAs) are small, noncoding RNAs that are believed to play
fundamental roles in tumorigenesis and tumor development at the posttranscriptional level …

Functional microRNAs (miRNAs) are produced from both arms of their precursors (pre-
miRNAs). Their abundances vary in context-dependent fashion spatiotemporarily and there …

Altered expression of the microRNA-34 family has been determined to be involved in the
pathogenesis of many cancers. In this review, the current knowledge of the cancer-related …

As rheumatologic diseases became understood to be autoimmune in nature, the drugs used
to treat this group of conditions has evolved from herbal or plant derived anti-inflammatory …

Epigenetics is a key mechanism regulating the expression of genes. There are three main
and interrelated mechanisms: DNA methylation, post-translational modification of histone …