Introduction: The frequency of CYP2D6 alleles, related to either a lack of or increased
enzymatic activity, which may lead to poor metabolism (PM) or ultrarapid metabolism (UM) …

[Frontiers in Bioscience E6, 377-386, June 1, 2014] 377 Genetic polymorphisms associated
with antiepileptic metabolism Miguel A Page 1 [Frontiers in Bioscience E6, 377-386, June 1 …

Genetic polymorphisms of CYP2C9 significantly influence the pharmacokinetics and
pharmacodynamics of some drugs, which might result in adverse drug effects and …

Aim: To evaluate the possible association between polymorphisms in CYP2C19 and the
pharmacokinetics of omeprazole, rabeprazole and pantoprazole. Materials & methods: 151 …

Background: In children and adolescents with familial hypercholesterolemia (FH)
pharmacotherapy with statins is the cornerstone in the current regimen to reduce low-density …

Abstract The cytochrome P450 (CYP450) enzyme family is involved in the oxidative
metabolism of many therapeutic drugs and various endogenous substrates. These enzymes …

Objective Warfarin represents the most commonly prescribed oral anticoagulants, which
functions as an antagonist of vitamin K, an essential factor of blood coagulation cascade …

Genetic variation in the regulation, expression and activity of genes coding for Phase I,
Phase II drug metabolizing enzymes (DMEs) and drug targets, can be defining factors for the …

Background Two variants in the gene encoding the cytochrome P450 2C9 enzyme
(CYP2C9) are considered the most significant genetic risk factors associated with bleeding …

Background: One of the promises of human genetics is individualized therapy. Therefore, we
evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a …