The spectrum of mixed brain pathologies expands beyond accompanying vascular
pathology in brains with Alzheimer's disease-related pathology. Co-occurrence of …

An abnormal expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the
chromosome 9 open reading frame 72 gene (C9ORF72) is the most common genetic …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

Fifty-eight autopsies of patients with primary progressive aphasia are reported. Twenty-three
of these were previously described (Mesulam et al., 2008) but had their neuropathological …

Abstract TDP-43 immunoreactivity occurs in 19–57% of Alzheimer's disease (AD) cases.
Two patterns of TDP-43 deposition in AD have been described involving hippocampus …

We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding
protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD) …

Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …

Neurodegenerative diseases (NDs) are defined by the accumulation of abnormal protein
deposits in the central nervous system (CNS), and only neuropathological examination …

The term frontotemporal lobar degeneration (FTLD) refers to a group of progressive brain
diseases, which preferentially involve the frontal and temporal lobes. Depending on the …

Variants in transmembrane protein 106 B (TMEM106B) modify the disease penetrance of
frontotemporal dementia (FTD) in carriers of progranulin (GRN) mutations. We investigated …