The bone marrow niche for haematopoietic stem cells
SJ Morrison, DT Scadden - Nature, 2014 - nature.com
Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …
Haematopoiesis provides a model for understanding mammalian stem cells and their …
Chemokines and chemokine receptors: positioning cells for host defense and immunity
JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …
of all immune cells. Although chemokines were initially appreciated as important mediators …
[HTML][HTML] Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations
Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment
for malignancies such as multiple myeloma (MM) and lymphomas. Various changes in the …
for malignancies such as multiple myeloma (MM) and lymphomas. Various changes in the …
[HTML][HTML] The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …
function by mediating the homing of progenitor cells in the bone marrow and regulating their …
Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment
A Ludin, S Gur-Cohen, K Golan… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …
Autonomic regulation of cellular immune function
DL Bellinger, D Lorton - Autonomic Neuroscience, 2014 - Elsevier
The nervous system and the immune system (IS) are two integrative systems that work
together to detect threats and provide host defense, and to maintain/restore homeostasis …
together to detect threats and provide host defense, and to maintain/restore homeostasis …
DLIN-KC2-DMA lipid nanoparticle delivery of modified polynucleotides
A De Fougerolles, KM Wood, SM Elbashir… - US Patent …, 2014 - Google Patents
2014-12-19 Assigned to MODERNA THERAPEUTICS, INC. reassignment MODERNA
THERAPEUTICS, INC. CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING …
THERAPEUTICS, INC. CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING …
Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling
Adult hematopoietic stem cells (HSCs) are maintained in specialized niches within the bone
marrow under steady-state conditions and mobilize for extramedullary hematopoiesis during …
marrow under steady-state conditions and mobilize for extramedullary hematopoiesis during …
Advances in stem cell mobilization
RK Hopman, JF DiPersio - Blood reviews, 2014 - Elsevier
Use of granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood
hematopoietic progenitor cells (HPCs) has largely replaced bone marrow (BM) as a source …
hematopoietic progenitor cells (HPCs) has largely replaced bone marrow (BM) as a source …
G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling
LG Schuettpelz, JN Borgerding, MJ Christopher… - Leukemia, 2014 - nature.com
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells
(HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and …
(HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and …