Significance: The evolution of the lungs and circulatory systems in vertebrates ensured the
availability of molecular oxygen (O2; dioxygen) for aerobic cellular metabolism of internal …

Sepsis is a systemic inflammatory response to infection and a major cause of death
worldwide. Because specific therapies to treat sepsis are limited, and underlying …

High levels of inspired oxygen, hyperoxia, are frequently used in patients with acute
respiratory failure. Hyperoxia can exacerbate acute respiratory failure, which has high …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains poorly
understood. Cellular senescence and apoptosis contribute to the development of COPD; …

Cigarette smoke extracts (CSE) may play a significant role in diseases of the upper airway
including chronic rhinosinusitis. Even short term exposure of cigarette smoke has adverse …

Background: Epidemiological evidence suggests that HIV-infected individuals are at
increased risk of lung cancer, but no data exist because large computed tomography (CT) …

Emphysema is characterized by loss of lung elasticity and irreversible air space
enlargement, usually in the later decades of life. The molecular mechanisms of emphysema …

Oxidants play an important role in homeostatic function, but excessive oxidant generation
has an adverse effect on health. The manipulation of Reactive Oxygen Species (ROS) can …

From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our
current focus on drug development to treat multiple pathologies related to this enzyme …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and
mortality in the United States and an epidemic worldwide. COPD pathologically manifests as …