The neurodegenerative diseases are a diverse group of disorders characterized by
progressive loss of specific groups of neurons. These diseases affect different populations …

Fused in sarcoma/translocated in liposarcoma (FUS/TLS or FUS) is a multifunctional DNA-
/RNA-binding protein that is involved in a variety of cellular functions including transcription …

The RNA-binding protein fused-in-sarcoma (FUS) has been associated with amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two …

Dominant mutations in FUS/TLS cause a familial form of amyotrophic lateral sclerosis (fALS),
where abnormal accumulation of mutant FUS proteins in cytoplasm has been observed as a …

Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human
biology and pathogenesis. RBPs are essential players in RNA processing and metabolism …

Mutations in the RNA-binding protein FUS have been shown to cause the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). We investigate whether …

Pathological alteration of TDP-43 (TAR DNA-binding protein-43), a protein involved in
various RNA-mediated processes, is a hallmark feature of the neurodegenerative diseases …

NKAP is a highly conserved protein with roles in transcriptional repression, T-cell
development, maturation and acquisition of functional competency and maintenance and …

In eukaryotic cells, gene activity is not directly reflected by protein levels because mRNA
processing, transport, stability, and translation are co-and post-transcriptionally regulated …

Résumé Le sarcome de Ewing est la seconde tumeur pédiatrique de l'os la plus fréquente.
Elle est caractérisée par une translocation chromosomique résultant à la fusion de EWSR1 …