The right ventricle in pulmonary arterial hypertension
R Naeije, A Manes - European respiratory review, 2014 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a right heart failure syndrome. In early-stage PAH,
the right ventricle tends to remain adapted to afterload with increased contractility and little …
the right ventricle tends to remain adapted to afterload with increased contractility and little …
The role of vascular endothelial growth factor in pulmonary arterial hypertension. The angiogenesis paradox
NF Voelkel, J Gomez-Arroyo - American journal of respiratory cell …, 2014 - atsjournals.org
Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis
leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …
leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …
Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle–like cells in pulmonary …
Background—Pericytes and their crosstalk with endothelial cells are critical for the
development of a functional microvasculature and vascular remodeling. It is also known that …
development of a functional microvasculature and vascular remodeling. It is also known that …
Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay
A Huertas, F Perros, L Tu, S Cohen-Kaminsky… - Circulation, 2014 - Am Heart Assoc
Huertas et al Immune/Endothelial Dysregulation in PAH 1333 comprise pulmonary
transmural inflammatory cell infiltrates with focal vessel wall necrosis and fibrinoid …
transmural inflammatory cell infiltrates with focal vessel wall necrosis and fibrinoid …
Changes in right ventricular function measured by cardiac magnetic resonance imaging in patients receiving pulmonary arterial hypertension–targeted therapy: the …
AJ Peacock, S Crawley, L McLure… - Circulation …, 2014 - Am Heart Assoc
Background—Most measures that predict survival in pulmonary hypertension (PH) relate
directly to, or correlate with, right ventricular (RV) function. Direct assessment of RV function …
directly to, or correlate with, right ventricular (RV) function. Direct assessment of RV function …
Evidence for the involvement of type I interferon in pulmonary arterial hypertension
Rationale: Evidence is increasing of a link between interferon (IFN) and pulmonary arterial
hypertension (PAH). Conditions with chronically elevated endogenous IFNs such as …
hypertension (PAH). Conditions with chronically elevated endogenous IFNs such as …
Proinflammatory cytokine levels are linked to death in pulmonary arterial hypertension
JL Cracowski, F Chabot, J Labarère… - European …, 2014 - Eur Respiratory Soc
Recent data suggest that inflammatory processes play a major role in pulmonary vascular
remodelling in patients with idiopathic, heritable, and drug-or toxin-induced (ihd) pulmonary …
remodelling in patients with idiopathic, heritable, and drug-or toxin-induced (ihd) pulmonary …
Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice
L Li, C Wei, IK Kim, Y Janssen-Heininger, S Gupta - Hypertension, 2014 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary disorder with
significant morbidity and mortality in patients with various lung and heart diseases. PAH is …
significant morbidity and mortality in patients with various lung and heart diseases. PAH is …
IL-32 promotes angiogenesis
IL-32 is a multifaceted cytokine with a role in infections, autoimmune diseases, and cancer,
and it exerts diverse functions, including aggravation of inflammation and inhibition of virus …
and it exerts diverse functions, including aggravation of inflammation and inhibition of virus …
Inflammation in pulmonary hypertension: what we know and what we could logically and safely target first
S Cohen-Kaminsky, A Hautefort, L Price, M Humbert… - Drug discovery today, 2014 - Elsevier
Inflammation is important for the initiation and the maintenance of vascular remodeling in
most of the animal models of pulmonary arterial hypertension (PAH), and therapeutic …
most of the animal models of pulmonary arterial hypertension (PAH), and therapeutic …